Scott C. Weaver, PhD

John Sealy Distinguished University Chair in Human Infections and Immunity
Director, Institute for Human Infections and Immunity
Scientific Director, Galveston National Laboratory
Leon Bromberg Professor for Excellence in Teaching
Member, Sealy Center for Vaccine Development
Core member, Sealy Center for Structural Biology
Associate Member, Institute for Medical Humanities
E-mail:  sweaver@utmb.edu

Professional Education


Degree

Institution

Field of Study

Graduation Year

B.S.

The College of William and Mary, Williamsburg, VA

Biology and Music

1979

M.S.

Cornell University, Ithaca, NY
Advisors: Eddie Cupp, William Scherer

Medical Entomology

1982

Ph.D.

University of California, San Diego, La Jolla, CA
Advisor: John Holland

Molecular Biology and Virology

1993

Post-Doctoral

Yale University School of Medicine, New Haven, CT

 

1994

Honors


2009–Present

John S. Dunn Distinguished Chair in Biodefense

2007–Present

Leon Bromberg Professor for Excellence in Teaching

2007–2009

Edgar and Mary Frances Monteith Distinguished Professor in Viral Genetics

2007

Graduate Student Organization Award for Excellence in Teaching and Mentoring

2005–Present

Council, American Society of Tropical Medicine and Hygiene

2002

Dalrymple-Young Memorial Award, American Committee on Arthropod-borne Viruses

2000

Ho Wang Lee Lecturer, American Society for Virology Annual Meeting, Ft. Collins, Colorado

2000

Fogarty Senior International Fellow

Professional Affiliations


2005–Present

Council, American Society of Tropical Medicine and Hygiene (elected position).

2002–Present

American Committee on Arthropod-borne Viruses: Secretary-Treasurer (elected position).

1998–2000

American Committee on Arthropod-borne Viruses: Executive Council, Chair (elected position).

1997–Present

Subcommittee on the Interrelationships Among Catalogued Arboviruses (SIRACA), American Committee on Arthropod-borne Viruses.

Research Interests


Basic research on the genetics, ecology, evolution and pathogenesis of arthropod-borne viruses (arboviruses), virus-mosquito interactions, and vaccine development.

Selected Publications


  1. Brault AC, Powers AM, Ortiz D, Estrada-Franco JG, Navarro-Lopez R, Weaver SC. Venezuelan equine encephalitis emergence: Enhanced vector infection from a single amino acid substitution in the envelope glycoprotein. Proc Natl Acad Sci U S A 101 (31): 11344-9, 2004. PMCID: PMC509205.
  2. Deardorff E, Estrada-Franco J, Brault AC, Navarro-Lopez R, Campomanes-Cortes A, Paz-Ramirez P, Solis-Hernandez M, Ramey WN, Davis CT, Beasley DW, Tesh RB, Barrett AD, Weaver SC. Introductions of West Nile virus strains to Mexico. Emerg Infect Dis 12 (2): 314-8, 2006.
  3. Anishchenko M, Bowen RA, Paessler S, Austgen L, Greene IP, Weaver SC. Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation. Proc Natl Acad Sci U S A 103 (13): 4994-9, 2006. PMCID: PMC1458783.
  4. Wang E, Petrakova O, Adams AP, Aguilar PV, Kang W, Paessler S, Volk SM, Frolov I, Weaver SC. Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. Vaccine 25 (43): 7573-81, 2007. PMCID: PMC2094013.
  5. Smith DR, Adams AP, Kenney JL, Wang E, Weaver SC. Venezuelan equine encephalitis virus in the mosquito vector Aedes taeniorhynchus: infection initiated by a small number of susceptible epithelial cells and a population bottleneck. Virology 372 (1): 176-86, 2008. PMCID: PMC2291444.
  6. Coffey LL, Vasilakis N, Brault AC, Powers AM, Tripet F, Weaver SC. Arbovirus evolution in vivo is constrained by host alternation. Proc Natl Acad Sci USA 105 (19): 6970-5, 2008. PMCID: PMC2383930.
  7. Aguilar PV, Adams AP, Wang E, Kang W, Carrara AS, Anishchenko M, Frolov I, Weaver SC. Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence. J Virol 82 (10): 4920-30, 2008. PMCID: PMC2346730.
  8. Wang E, Volkova E, Adams AP, Forrester N, Xiao SY, Frolov I, Weaver SC. Chimeric alphavirus vaccine candidates for chikungunya. Vaccine 26 (39): 5030-5039, 2008. PMCID: PMC2571998.
  9. Adams AP, Aronson JF, Tardif SD, Patterson JL, Brasky KM, Geiger R, de la Garza M, Carrion R, Jr., Weaver SC. Common marmosets (Callithrix jacchus) as a nonhuman primate model to assess the virulence of eastern equine encephalitis virus strains. J Virol 82 (18): 9035-42, 2008. PMCID: PMC2546911.
  10. Quiroz E, Aguilar PV, Cisneros J, Tesh RB, Weaver SC. Venezuelan equine encephalitis in panama: fatal endemic disease and genetic diversity of etiologic viral strains. PLoS Negl Trop Dis 3 (6): e472, 2009. PMCID: PMC2697379.
  11. Vasilakis N, Deardorff ER, Kenney JL, Rossi SL, Hanley KA, Weaver SC. Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells. PLoS Pathog 5 (6): e1000467, 2009. PMCID: PMC2685980.
  12. Arrigo NC, Adams AP, Weaver SC. Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision. J Virol 84 (2): 1014-25, 2010. PMCID: PMC2798374.
  13. Deardorff ER, Forrester NL, Travassos da Rosa AP, Estrada-Franco JG, Navarro-Lopez R, Tesh RB, Weaver SC. Experimental Infections of Oryzomys couesi with Sympatric Arboviruses from Mexico. Am J Trop Med Hyg 82 (2): 350-3, 2010. PMCID: PMC2813180.
  14. Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC. Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol 84 (13): 6497-504, 2010. PMCID: PMC2903258.
  15. Auguste AJ, Lemey P, Pybus OG, Suchard MA, Salas RA, Adesiyun AA, Barrett AD, Tesh RB, Weaver SC, Carrington CV. Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas. J Virol. Online, 2010. PMCID: PMC2937779.
  16. Deardorff ER, Weaver SC. Vector competence of Culex (Melanoconion) taeniopus for equine-virulent subtype IE strains of Venezuelan equine encephalitis virus. Am J Trop Med Hyg 82 (6): 1047-52. PMCID: PMC2877410.
  17. Sherman MB, Weaver SC. The Structure of the Recombinant Alphavirus, Western Equine Encephalitis Virus, Revealed by Cryoelectron Microscopy. J Virol. Online, 2010. PMCID: PMC2937749.
  18. Arrigo NC, Adams AP, Watts DM, Newman PC, Weaver SC. Cotton rats and house sparrows as hosts for North and South American strains of eastern equine encephalitis virus. Emerg Infect Dis 16 (9): 1373-80, 2010. PMCID: not yet available.
  19. Kenney JL, Volk SM, Pandya J, Wang E, Liang X, Weaver SC. Stability of RNA virus attenuation approaches. Vaccine, 2010. PMCID: not yet available.
  20. Tsetsarkin KA, Chen R, Leal G, Forrester N, Higgs S, Huang J, Weaver SC. Chikungunya Virus Emergence is Constrained in Asia by Lineage-Specific Adaptive Landscapes. Proc. Natl. Acad. Sci. U.S.A.: in press, 2011.
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